In the case report, a 51 – year-old man with the chief complaint of a penile mass that had been present for 8 months presented. The mass appeared rapidly over a period of 3 months and then stabilizes. The patient denied pain, but had a 30-degree dorsolateral curvature which inhibited sexual intercourse. The patient also had an hourglass deformity of his penis to check. Erections were less firm than before but respond to sildenafil. Sonography was performed revealed calcified calcified areas in the tunica albuginea of the left cavernous, a back and ventral. The patient was prescribed pentoxifylline 400 mg three times daily and took the drug for 6 months. After re-evaluation at 6 months, his penis had straightened up to 10 degrees of curvature, but still demonstrated an hourglass deformity.
Pentoxifylline or Trental, in humans is used in a variety of inflammatory and fibrotic conditions, including radiation fibrosis, radiation proctitis, cystic fibrosis, pneumonitis and steatohepatitis radiation. The mechanism is not fully understood, pentoxifylline blocks of the transforming growth factor B1 – mediated pathway of inflammation, prevents the deposition of collagen type 1, and acts as a non-specific phosphodiesterase inhibitor.Yorkie turns out to mystery protein, report the researchers to be in these experiments, Pan and colleagues show to. The hippo phosphorylation cascaded, tumor-related phosphate group to the Yorkie he from him.
The authors of the paper in addition to Pan be Shian Wu of Hopkinsville , and Jianbin Huang, Jose Barrera and Krista Matthews on UT Southwestern. The by the National Institute of Health.